Table 2.
Neuropsychological assessment recommendations.
| Neuropsychological assessments should be conducted at 12 and 18 years in all patients |
|---|
| If any of the stated risk factors applies, perform (additional) neuropsychological assessment: Non-optimal metabolic control; <50% of the Phe levels are out of target range over a period of 6–12 months (depending on age <12 or >12 years) Problems at school or work Concerns of parents/caregivers/family/teachers Concern of PKU patient Concern of metabolic team |
| Cognitive Domains for Inclusion |
| Estimation of intelligence Academic achievement Immediate, divided, and sustained attention Speed of processing Visuo-spatial functioning Verbal new learning and memory Expressive and receptive language Motor speed and coordination Executive functions: Working memory Inhibitory control/self-monitoring Planning and organization Cognitive flexibility/shifting Verbal fluency Social cognition Psychiatric screening Psychosocial adjustment/quality of life Behavioral rating scales |