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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Neurobiol Dis. 2018 Aug 24;120:1–11. doi: 10.1016/j.nbd.2018.08.013

Figure 3: GPNMB levels in brain regions of mice modelling alpha-synucleinopathy are not different compared to age-matched WT mice.

Figure 3:

Whole brain homogenates from age-matched wild-type (WT; n=6) or Thy1 alpha-synuclein overexpressing (Thy1-aSYN; n=6) mice display similar levels of (A) glucocerebrosidase (GCase) activity and (B) glycosphingolipids such as glucosylceramide (GlcCer) and glucosphingosine (GluSph). Results are mean ±SEM. (C) GPNMB levels in striatum (STR), motor cortex (MCtx), and substantia nigra (SN) motor cortex homogenates from age-matched WT (n=3–6) and Thy1-aSYN mice (n=6–9) were measured by ELISA and show that transgenic animals display similar GPNMB levels to WT mice in these brain regions. Results are mean normalized to corresponding WT brain region ±SEM. No significant differences were observed with statistical tests (Panel A: unpaired two-tailed Students T-test; Panels B and C: two-way ANOVA).