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. Author manuscript; available in PMC: 2019 Sep 17.
Published in final edited form as: Bioorg Med Chem Lett. 2018 Dec 15;29(3):413–419. doi: 10.1016/j.bmcl.2018.12.031

Fig. 2.

Fig. 2.

Peptidomimetic 13 (ZL0177) modulates Nav1.6 mediated Na + currents. (A) Representative traces of Nav1.6-mediated transient Na+ currents (INa+) recorded from HEK-Nav1.6 stable cells treated with either DMSO (0.02%; blue) or ZL0177 (10 μM; orange) in response to voltage steps from −120 mV to +60 mV from a holding potential of −70 mV (inset). (B) Representative traces of experimental groups described in A in which tau (τ) of transient INa+ was estimated from a one-term exponential fitting function (red dotted line). (C) Current-voltage relationships of transient INa+ from experimental groups described in A and B. (D) Summary bar graph of peak current densities derived from C. (E) Summary bar graph of tau calculated at −10 mV in the indicated experimental groups. Data are mean ± S.E.M. *, p < 0.05. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)