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. 2019 Sep 10;10:988. doi: 10.3389/fphar.2019.00988

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Copyright © 2019 Wang, Xin, Xu, Yu and Shou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Potential active ingredient-target-pathways network of EXD acting on osteoporosis. The network was based on the interaction among ingredients in EXD, active components, and osteoporosis-related targets. Red nodes represented the ingredients; green nodes represented the targets; blue nodes represented the osteoporosis-related pathways. (B) KEGG pathways for potential targets of Erxian decoction. (C) The interaction among herbs, components, and targets in PI3K-Akt signaling pathway.