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. 2019 Jan 8;26(9):1845–1858. doi: 10.1038/s41418-018-0255-8

Fig. 2.

Fig. 2

Reduced level of DNA damage in cells from centenarians. a Comet assay in young (yng), aged (old), and centenarians (cen) DF under basal condition. b Comet assay in yng, old, and cen DF upon 7.5 Gy of gamma radiation exposure. c Phospho-serine139-γ-H2AX (γ-H2AX) and actin protein level in yng, old, and cen DF treated or untreated with 5 µM doxorubicin for 24 h. d Rad51, γ-H2AX, and actin protein level in DF from yng, old, and cen, and Rad51 mRNA level in old and cen DF. e Confocal microscopy analysis of Rad51 in yng, old, cen DF at basal condition and upon exposure of 7.5 Gy of gamma radiation. f Telomere/single copy gene ratio (T/S) in DNA from yng (n = 8), old (n = 4), cen (n = 5) DF; data are presented as mean ± s.d.