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. 2019 Jan 15;26(10):1905–1917. doi: 10.1038/s41418-018-0259-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The expression of MORC2 negatively correlates with the differentiation status of gastric cancer. a Immunohistochemical analysis of MORC2 and C/EBPα expression in normal gastric tissues, well-moderate differentiation gastric cancer and differentiation poor gastric cancer tissues. Scale bar, 50 μm. Representative IHC images were shown. The levels of MORC2 and C/EBPα were analyzed in the different differentiation status of gastric cancer samples. b The levels of C/EBPα and MORC2 were analyzed with 40 cases of gastric tumor patients. The down-regulation of C/EBPα and up-regulation of MORC2 accounted for ~80% in 40 cases of gastric tumor patients. c Low C/EBPα expression accounted for 60% in high expression of MORC2 group. By analyzing the downloaded TCGA gastric cancer public data with expression values of MORC2 and C/EBPα, the expression level in normal tissues and tumor tissues was measured with respective media. Expression value higher than the media is identified as high expression. Vice versa, that is low expression. d Western blot detected the protein levels of c-myc and TFF1 when MORC2 or C/EBPα was overexpression in SGC-7901 gastric cancer cells. e QPCR detected the mRNA levels of c-myc and TFF1 when MORC2 was overexpression in SGC-7901 gastric cancer cells. f QPCR detected the mRNA levels of c-myc and TFF1 when MORC2 was knockdown in SGC-7901 gastric cancer cells. g Kaplan–Meier’s analyses illustrated that the 5-year survival rate according to MORC2 protein expression on 210 gastric cancer patients. The lower-expression group was defined as those at or below the median value (1.2-fold), whereas the higher-expression group consisted of patients expressing levels above (1.2-fold). h Model of the role of MORC2 in C/EBPα-mediated differentiation and tumorigenesis. In the absent of MORC2, C/EBPα plays a role in cell differentiation promotion and inhibition of cell proliferation, which may block tumorigenesis. While in the present of MORC2 overexpression, MORC2 interacts with C/EBPα and promotes the sumoylation of C/EBPα and its subsequent degradation, which will lead to tumorigenesis