Fig. 6.

TMEM268 deficiency causes cytoskeleton remodeling and cytoskeletal network damage. a, b Control and Cas9-TMEM268/BGC823 cells were plated on glass slides for 24 h, then an immunofluorescence assay performed with the indicated antibodies. Nuclei were stained with Hoechst 33342. Representative images obtained from confocal microscopy are shown. Scale bars, 10 μm. c Changes in the microfilament network structure in control and Cas9-TMEM268/BGC823 cells were observed by transmission electron microscopy. Representative images obtained are shown