Fig. 6.

Conditional deletion of Pdgfra in the mesenchyme of the developing external genitalia at later embryonic stages resulted in milder defective external genitalia development. Tamoxifen was given to pregnant mice at E10.5 and E11.5 (a) or E11.5 and E12.5 (b), embryos were collected at E14.5 and/or E17.5 for morphology analysis. Black arrowhead indicates the location of the urethral opening. Black arrow indicates the proximal untubularized urethra. pp prepuce, uf urogenital fold, ls labioscrotal fold, g glans. n = number of embryos analyzed