Table 1.
Phosphoproteins used in multiplex analysis
| Protein | Full name | Gene names | Phosphorylation site | Function | UniProt entry |
|---|---|---|---|---|---|
| MEK | Dual specificity mitogen-activated protein kinase kinase-1 | MAP2K1, MEK1, PRKMK1 | S217/S221 | Cell growth, survival, differentiation | Q02750 |
| ERK | Mitogen-activated protein kinase-1 | MK01, MAPK1, ERK2, PRKM1, PRKM2 | T202/Y204 | Cell growth, adhesion, survival, differentiation | P28482 |
| AKT | RAC-alpha serine/threonine-protein kinase | AKT1, PKB, RAC | S473 | Metabolism, proliferation, cell survival, cell growth, angiogenesis | P31749 |
| FAK | Focal adhesion kinase-1 | PTK2, FAK, FAK1 | Y397 | Cell migration, adhesion, cell cycle, progression, proliferation, apoptosis | Q05397 |
| C-JUN | Transcription factor AP-1 | JUN | S63 | Cell cycle progression, proliferation angiogenesis, apoptosis | P05412 |
| STAT3 | Signal transducer and activator of transcription 3 | STAT3, APRF | Y705 | Cell growth, proliferation, migration, differentiation, survival, apoptosis | P40763 |
| P53 | Cellular tumour antigen p53 | TP53, P53 | S46 | Growth arrest, apoptosis, cell cycle regulation | P04637 |
| IκBa | NF-kappa-B inhibitor alpha | NFKBIA, IKBA, MAD3, NFKBI | S32/S36 | Proliferation, apoptosis | P25963 |
| WNK | Serine/threonine-protein kinase WNK1 | WNK1, HSN2, KDP | T60 | Electrolyte homeostasis, cell signalling, survival, proliferation | Q9H4A3 |
| CREB | Cyclic AMP-responsive element-binding protein 1 | CREB1 | S133 | Proliferation, migration, tumour suppression | P16220 |
| PTN11 | Tyrosine-protein phosphatase non-receptor type 11 | PTPN11, PTP2C, SHPTP2 | Y542 | Signal transducer | Q06124 |