Fig. 3.

Loss of caspase-12 does not provide additional protection against LPS-induced lethal septic shock above the protection afforded by combined loss of caspases-1 and -11. a Survival of mice of the indicated genotypes after i.p. injection with 18 mg/kg LPS (left panel). Serum levels of IL-18 at 4 h after i.p. injection of 18 mg/kg LPS (Cont. represents no treatment). b Similar presentation of data as in a, but mice were injected i.p. with 54 mg/kg LPS. Symbols represent individual mice. Data are presented as mean ± S.E.M. Adjusted p values are supplied in Supplementary Table 2. Results of the levels of cytokines were analysed by one-way ANOVA