Fig. 1.

miR-142-3p is the specific miRNA downregulated in NPC with distant metastasis. a Heatmap clustering of differentially expressed miRNAs with a threshold of >1.25-fold change and P value < 0.05 symmetrically in NPC with distant metastasis (n = 57) and NPC without distant metastasis (n = 57). Columns: individual samples; Rows: miRNAs; Blue: low expression; yellow: high expression. b Volcano plot for the visualization of notably differentially expressed miRNAs. c Real-time PCR analysis of miR-142-3p expression in an internal set of 94 nondistant metastatic NPC and 36 distant metastatic NPC. P value was determined by one-tailed t test. d Published NanoString analysis of miR-142-3p expression in an independent set of 211 nondistant metastatic NPC and 35 distant metastatic NPC from Toronto, Canada (GSE70970). P value was determined by one-tailed t test