Fig. 4.

miR-142-3p attenuates NPC cell metastasis and EMT. a, b Representative images and quantification of wound-healing (a) and transwell (b) assays in NPC cells transfected with miR-142-3p mimics or control. Mean (n = 3) ± s.d. Student’s t test, *P < 0.05, **P < 0.01. c Western blot of E-cadherin, a-catenin, Fibronectin, and Vimentin. d A total of 1×10⁶ SUNE-1 cells were intravenously injected via the tail vein, and the formation of lung metastatic colonization was evaluated after 8 weeks. Representative images and quantification of macroscopic and microscopic metastatic nodules in lungs of mice with or without stable miR-142 overexpression. The arrows indicated tumors. Mean (n = 9) ± s.d. Student’s t test, **P < 0.01. Scale bar, 100 μm