Fig. 8.

miR-142 hypermethylation is associated with metastasis in NPC patients. a, b Kaplan−Meier analysis of overall survival (OS, a) and distant metastasis-free survival (DMFS, b) according to the miR-142 methylation status in 228 NPC patients in the training cohort. The P value was determined using the log-rank test. c, d Kaplan−Meier analysis of OS (c) and DMFS (d) in 164 NPC patients in the validation cohort. The P value was determined using the log-rank test. e Proposed model for miR-142-3p downregulation in NPC. DNMT1-mediated epigenetic silencing of miR-142-3p determines ZEB2 activation and leads to EMT and metastasis in NPC