Fig. 7.

Late-stage deficiency of PDK1 leads to reduced NK cell-mediated immunosurveillance. NK cells in vivo functions, including MHC-II mismatched splenocyte rejection (a, b), RMA-S clearance (c, d) and B16 melanoma lung metastasis (e, f), were analyzed as detailed for Fig. 2. All data represent at least three independent experiments, and calculated data are shown as the means ± s.d