Fig. 3.

Parental Mutant p53 MSCs display increased mitochondrial mass compared to Parental WT p53 MSCs. a, b Representative EM micrographs (scale bar in big and small panels, 1 µM and 500 nm, respectively). Arrows indicates representative mitochondria. c Quantitation of the EM micrographs (at least 30 images per sample), show increased mitochondrial size in parental p53Mut Vs parental p53WT MSCs. One-way, two-sided ANOVA. d Relative mRNA expression of PGC1-β. Data are presented as mean ± SEM of at least three independent experiments. One-way, two-sided ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001