Table 2.

SSOs as drugs for modulating RNA splicing in cancer

Target	Splicing events	Short description	Refs
ATM	Intron 28 inclusion	Susceptibility to radiation in HEK293 cell lines	[102]
Bcl-x	Exon 2 skipping	Induction of apoptosis in human glioma cell lines	[75]
BRCA1	Exon 11 skipping	Enhancing the effect of PARP inhibitors in breast cancer	[103]
HER2	Exon 15 skipping	Induction of apoptosis in breast cancer cells	[104]
HER4	Exon 26 skipping	Decrease growth of breast cancer cells	[105]
MDM2	Exon 11 skipping	Susceptibility to DNA damage in breast cancer cells	[106]
MDM4	Exon 6 skipping	Inhibite melanoma growth	[107]
PKM	Exon 10 inclusion	Susceptibility to chemotherapy in pancreatic cancer cells	[108]
STAT3	Alternative 3′ SS	Induction of apoptosis in breast cancer cells	[109]
WT1	Exon 5 inclusion	Kill HL60 leukaemia cells	[110]