Fig. 2.

ABIN-1 deficiency increases antiviral responses of MEFs to Sendai virus. a, b ELISA analysis of IFN-β (a) and IL-6 (b) production upon Sendai virus infection at the indicated time points in the presence or absence of 10 μM Nec-1s in Abin-1^+/+, Abin-1^+/−, and Abin-1^−/− MEFs. Sendai virus strain: PI-1. Multiplicity of infection (MOI), 10. c Phosphorylation of IRF-3 upon Sendai virus infection for 0–24 h in Abin-1^+/+ and Abin-1^−/− MEFs. d Phosphorylation of IκBα upon Sendai virus infection for 0–8 h in MEFs. e Western blot analysis of caspase-11 expression upon Sendai virus infection for 0–16 h. Data are presented as the mean ± S.D. from at least three independent experiments. **P < 0.01, ***P < 0.001