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. 2019 Sep 5;2019:8712492. doi: 10.1155/2019/8712492

Figure 4.

Figure 4

Islet transplantation treatment activated the Nrf-2/HO-1 pathway in the testicular tissues of diabetes-induced rats. (a, b) Immunohistochemical staining (×400) (bar = 25 μm) and quantitative analysis of positive regions showing the expressions and typical distribution of HO-1 in testicular sections. Compared with those of the INS and DM groups, the expression level of HO-1 significantly increased after IT (n = 6 for each group). (c–g) Representative Western blot images of Nrf2, HO-1, and NQO1 and quantifications of their expression levels in testicular tissues. DM induced a marked decrease in these parameters. Treatment by IT significantly increased the expression of Nrf2, HO-1, and NQO1. The expressions of these proteins in the INS group were only slightly altered (n = 6 for each group). DM: diabetes mellitus; INS: insulin treatment; IT: islet transplantation. ∗P < 0.05 vs. control; &P < 0.05 vs. DM; +P < 0.05 vs. INS.