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. 2018 Jul 27;84(2):212–224. doi: 10.29024/aogh.909

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Copyright: © 2018 The Author(s)

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.

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Susceptibility windows of DNA-methylation due to environmental pollutants. The epigenome undergoes reprogramming at two relevant stages, the gametogenesis and the early embryo preimplantation representing vulnerable stages to enviornemental exposures. During gametogenesis and fertilization, a general demethylation followed by a re-methylation process occur, with the exception of imprinted genes. DNA-methylation patterns are reestablished by DNA methyl-transferases DNMT3a and DNMT3b [1]. 5 mC, 5-methylcytosine. BPA, bisphenol A. Cd, cadmium. As arsenic. Pb, lead. Hg, mercury.