Table 2.
Change in the Annual Incidence of HIV Infection over Time in the Intervention Group.✲
Region | Incidence Rate per 100 Person-Yr | Relative Rate (95% CI)† | ||
---|---|---|---|---|
Year 1 | Year 2 | Year 3 | ||
All regions | 0.43 | 0.38 | 0.31 | 0.68 (0.56–0.84) |
Kenya | 0.69 | 0.62 | 0.39 | 0.54 (0.39–0.75) |
Western Uganda | 0.35 | 0.35 | 0.38 | 1.03 (0.73–1.44) |
Eastern Uganda | 0.29 | 0.19 | 0.18 | 0.61 (0.39–0.95) |
The annual incidence rate of HIV infection per 100 person-years was calculated in three annual incidence cohorts of HIV-negative adults 15 years of age or older (including nonstable residents, persons who migrated into the community, and persons who migrated out) who had repeat annual HIV testing. At year 1, the analysis included 52,474 persons, representing 51,975 person-years of follow-up; at year 2, the analysis included 55,531 persons, representing 53,371 person-years of follow-up; at year 3, the analysis included 58,145 persons, representing 52,567 person-years of follow-up. For incident infections, the date of infection was imputed as the midpoint of the time between repeat HIV tests.
The relative rate (year 3 vs. year 1) was based on Poisson generalized estimating equations with an exchangeable covariance matrix, with adjustment for age, sex, and mobility (i.e., at least 1 month of the previous year spent outside the community).