Table 1.
Summary of clinical phenotype data for sickle cell patients used in the miRNA analysisa
| High-HbF Group | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subject # | Hgb (g/dl) | Hct (%) | Pits (× 103) |
WBC (× 103) |
Neutrophils ( × 103) |
Lymphocytes × ( 103) |
NRBC(%) | Reticulocyte Count (%) |
HbF (%) |
| 001 | 9.5 | 28.6 | 269 | 8.1 | 5.8 | 1.3 | 0 | 5.0 | 30.6 |
| 003 | 10.5 | 30.9 | 563 | 11.4 | 5.0 | 4.3 | 0 | 5.7 | 21.8 |
| 08A | 7.4 | 21.7 | 192 | 4.2 | 2.1 | 1.3 | 3 | 8.8 | 25.0 |
| 014 | 8.1 | 22.9 | 469 | 15.1 | 5.7 | 7.7 | 0 | 9.8 | 16.8 |
| 015 | 8.7 | 25.4 | 416 | 14.1 | 5.1 | 7.5 | 0 | 8.8 | 27.5 |
| 016 | 7.6 | 27.2 | 499 | 17.5 | 7.5 | 7.4 | 1 | 12.7 | 19.2 |
| Mean ± SEM 8.63 ± 0.49 Low-HbF Group |
26.11 ± 1.42 | 404.67 ± 60.17 | 11.7 ± 2.00 | 5.2 ± 0.72 | 4.917 ± 1.25 | 0.67 ± 0.49 | 8.467 ± 1.15 | 23.48 ± 2.12 | |
| 004 | 7.1 | 20.1 | 380 | 15.5 | 6.2 | 5.9 | 6 | 10.5 | 3.8 |
| 008 | 7.0 | 20.1 | 693 | 11.1 | 4.2 | 6.2 | 2 | 13.4 | 3.0 |
| 009 | 7.8 | 24.8 | 641 | 13.8 | 8.7 | 3.7 | 0 | 9.0 | 0.9 |
| 011 | 7.6 | 22.8 | 570 | 15.60 | 8.2 | 5.70 | 2 | 12.0 | 6.2 |
| 011A | 8.4 | 28.9 | 461 | 10.8 | 5.9 | 2.5 | 0 | 8.2 | 6.2 |
| 012A | 8.9 | 28.1 | 384 | 10.9 | 4.9 | 4.5 | 1 | 5.6 | 0.1 |
| Mean ± SEM 7.8 ± 1.30 | 24.13 ± 1.56 | 521 ± 54.35 | 12.95 ± 0.94 | 6.35 ± 0.73 | 4750 ± 0.59 | 1.83 ± 1.02 | 9.783 ± 1.42 | 3.37 ± 1.05 | |
| p valuesb | 0.1766 | 0.3698 | 0.1802 | 0.5943 | 0.2876 | 0.9067 | 0.1859 | 0.4353 | 0.0001* |
a
Shown are the values obtained for the individual complete blood counts and differential and reticulocyte counts for the 12 children and adults (011A and 012A) with HbSS included in the miRNA analysis. The mean ± standard error of the mean (SEM) is shown for each parameter. The Student t test was used to determine significant difference between the two study groups; p < 0.05 was considered statistically significant.
b
p values generated using the Student t test for data collected for each parameter for the two groups.Hgb=hemoglobin, Hct= hematocrit, Plts=platelet count, WBC=white blood cell count, NRBC=nucleated red blood cells