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. 2019 Sep 10;12:215. doi: 10.3389/fnmol.2019.00215

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Copyright © 2019 Wang, Liao, Li, Chen and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between TUG1 and miR-145a-5p. (A) Putative binding sites revealed by bioinformatics analysis. (B) Direct binding further confirmed by biotin-labeled RNA-RNA pull-down assay. (C) Quantification of RNAs by qRT-PCR. OGD-induced up-regulation of TUG1 was sufficiently turned over by miR-145a-5p inhibitor, vice versa, OGD-induced down-regulation of miR-145a-5p was sufficiently turned over by TUG1 siRNA, suggesting a negative interaction between TUG1 and miR-145a-5p. *P < 0.05 vs. the corresponding control. NC, negative control. n = 4.