Figure 2.

Exo70 in cell migration and invasion. During cell migration, Exo70 generates membrane curvature, which contributes to membrane protrusion at the leading edge. Exo70 also promotes the interaction of the Arp2/3 complex with its activators such as WAVE2, stimulating actin filament nucleation and branching. During cell invasion, Exo70, together with other exocyst components, participates in the secretion of matrix metalloproteinases (MMPs), which mediate ECM degradation by invadopodia. Phosphorylation of Exo70 by ERK promotes the assembly of Exo70 with other exocyst components, thereby enhancing MMP exocytosis.