Skip to main content
. 2019 Sep 17;2019(9):CD003248. doi: 10.1002/14651858.CD003248.pub4

Kumar 2015.

Methods Randomised controlled trial
Participants Inclusion criteria
  • Babies born between 32 0/7 and 36 6/7 gestation

  • Born vaginally or by lower segment CS

  • Singleton pregnancies

  • N = 200 babies (but 10 lost to follow‐up)


Exclusion criteria
  • Umbilical cord length less than 25 cm, or were non‐vigorous at birth. Multiple births (twins, triplets), those born to Rh negative or retrovirus positive mothers, hydrops fetalis and those with major congenital anomalies, cord prolapse or cord anomalies like true knots were also excluded.

  • Babies born to mothers with complications such as placental abruption, placental implantation disorders (placenta previa or accreta) or chorioamnionitis were excluded only if they were born limp.

Interventions Intervention: UCM
  • After clamping and cutting the cord at 25 cm from the umbilicus, the cord was milked 3 times at 10 cm/sec

  • N = 100 babies (3 lost to follow‐up only relevant for longer‐term outcomes)


Comparator: ECC
  • Cord clamped immediately

  • N = 100 babies (7 lost to follow‐up (only relevant for longer term outcomes) and 3 samples haemolysed)


Additional information
  • Gestational subgroup: > 32‐34 weeks' gestation

  • Resuscitation with cord intact: not available

  • Access to NICU: yes

  • Length of delay: n/a

  • Baby placed: under radiant warmer

  • Uterotonic: given soon all births (IM for vaginal births and IV for CS)

  • UCM: cord cut


Comparison 7
UCM vs ECC (subgroup by gestation)
Subgroup 2: > 32‐34 weeks' gestation
Comparison 8
UCM vs ECC (subgroup by type of intervention)
Subgroup 2: cord cut before UCM
Outcomes Primary
  • Hb and serum ferritin at 6 weeks


Secondary
  • Jaundice needing phototherapy; respiratory distress; need for oxygen; polycythaemia

  • Hb, packed cell volume and bilirubin) in first 48 hrs of life; Hb at 48 hrs; Hct at 48 hrs

  • Bilirubin mg/dL in first 48 hrs

  • At 30 mins of life; Mean BP mmHg; HR/min; Resp rate/min

Notes Setting: Department of Pediatrics and Obstetrics of a tertiary care institute in Northern India.
Dates: September 2013 to August 2014
Declaration of interest: no competing interests reported
Trial funding source: no funding.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote:“…online generated random number list and assigned even numbers to early cord clamping (control) group and"
Allocation concealment (selection bias) Low risk Quote:“The numbers were written on small slips and placed in serially numbered opaque sealed envelopes. Sealed envelope was opened by a delivery room staff nurse, just"
Blinding of participants and personnel (performance bias) 
 All outcomes High risk No information provided. Clinicians at the birth cannot be blinded but it is unclear if women were blinded.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk No information but most of outcomes are laboratory tests – though there are a few clinical outcomes – so unclear.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk UCM group lost 3/100 and ECC group lost 7/100 for clinical outcomes. So well under 20%.
Selective reporting (reporting bias) Unclear risk We did not assess the trial protocol
Other bias Low risk No indication of other biases,.