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. 2019 Sep 17;2019(9):CD003248. doi: 10.1002/14651858.CD003248.pub4

Nelle 1998.

Methods Randomised controlled trial. Randomisation by sealed opaque envelopes.
Participants Inclusion criteria
  • Infants < 1500 g.

  • Born by CS

  • N = 19 babies


Exclusion criteria
Interventions Intervention: DCC
  • Cord clamping after 30 secs and positioning of the infant 30 cm below placenta

  • N = 11 babies


Comparator: ECC
  • Cord clamped immediately after birth

  • N = 8 babies


Additional information
  • Gestational subgroup: < 32‐34 weeks' gestation

  • Resuscitation with cord intact: not available

  • Access to NICU: yes

  • Length of delay: 30 secs

  • Baby placed: low

  • Uterotonics: no information

  • UCM: n/a


Comparison 1
DCC with neonatal resuscitation after cord clamping vs ECC (subgroup by gestation)
Subgroup 1: < 32‐34 weeks' gestation
Comparison 2
DCC with neonatal resuscitation after cord clamping vs ECC (subgroup by type intervention)
Subgroup 2: DCC at < 1 min with baby low (+ gravity)
Outcomes Outcomes:
  • Mean arterial blood pressure, left ventricular output, mean cerebral blood flow velocity, Hb, Hct, systemic and cerebral Hb transport, volume expansion during the first 24 hrs.

Notes No data for the review
Setting: Germany
Dates: not reported
Declaration of interest: not reported
Trial funding source: not reported
Further information:
  • Reported as abstract only

  • There is lack of clarity as to whether this was an RCT or not. However, as the study provides no data for the review this issue was considered relatively unimportant.

  • M Nelle kindly provided additional information regarding this study.

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not described.
Allocation concealment (selection bias) Unclear risk Sealed, opaque envelopes (information provided by the author).
Blinding of participants and personnel (performance bias) 
 All outcomes High risk No blinding. Not clear whether outcomes would be affected by lack of blinding. Other aspects of care may have been affected by lack of blinding.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk No blinding. Not clear whether outcomes would be affected by lack of blinding. Other aspects of care may have been affected by lack of blinding.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Not clear whether full data were available for all participants.
Selective reporting (reporting bias) Unclear risk Reported in brief abstract.
Other bias Unclear risk Very little information on study methods.