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. 2019 Sep 17;2019(9):CD003248. doi: 10.1002/14651858.CD003248.pub4

Rana 2017.

Methods Randomised, parallel group trial
Participants Inclusion criteria
  • Newborn infant with gestation less than 34 weeks

  • N = 100 babies


Exclusion criteria
  • Known congenital malformations; serious maternal illnesses (a) severe pre‐eclampsia or eclampsia (b) third stage PPH (c) uncompensated heart disease; twins, triplets or babies requiring resuscitation

Interventions Intervention: DCC
  • Cord clamping at 120 secs after the birth of baby

  • N = not reported


Comparator: ECC
  • Cord clamping within 30 secs after the birth of baby

  • N = not reported

Outcomes Primary
  • Hyperbilirubinemia and polycythaemia during initial 7 days of life in infants


Secondary
  • Requirement for resuscitation

  • Skin temperature at 5 mins and 30 mins of age

  • Incidence of RDS

  • Culture positive or culture negative sepsis

  • Hypoperfusion requiring fluid boluses and/or vasopressors

  • Need for blood transfusion

  • IVH

  • NICU and hospital stay

Notes No usable data for this review
Setting: no information ‐ authors live in India
Dates: Started 15 April 2014 but no information on completion date though trial reported as complete on trial registration form.
Declaration of interest: not reported
Trial funding source: Maulana Azad Medical College (Government Medical College), Bahadur Shah Zafar Marg, New Delhi 110002
Further information:
  • Trial Registration: CTRI/2013/04/003529

  • We will write to authors for further information, in particular how many were allocated to each group.

  • Previous reporting of this study was under Agarwal 2014, but we consider the Rana 2017 the main publication now.

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated randomisation (information from trial registration).
Allocation concealment (selection bias) Low risk Sequentially numbered, sealed, opaque envelopes (information from trial registration).
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Clinicians cannot be blinded.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk There is no information to show that the assessments of outcomes were blinded. For lab tests it is likely there was blinding ‐ but unclear for the clinical outcomes.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk No information
Selective reporting (reporting bias) Unclear risk We did not assess the trial protocol.
Other bias Unclear risk There is very little information in this short 'Letter to the Editor'.