Ruangkit 2017.

Trial name or title	A randomised controlled trial of immediate versus delayed umbilical cord clamping in preterm infants of multiple births
Methods	Randomised controlled trial
Participants	Inclusion criteria Twins at 28 ‐ 36 weeks' gestation Exclusion criteria Prenatally diagnosed major congenital anomaly in any infants twin to twin transfusion syndrome TTTS or twin anaemic polycythaemica sequence TAPS discordant twins weight difference of more than 20 any intrauterine fetal death hydrops antepartum or intrapartum haemorrhage such as placental abruption or uterine rupture or declination by the medical team obstetrician or paediatrician in performing the intervention
Interventions	Intervention: DCC Clampint at 30‐60 secs. In the DCC group, after each infant is delivered and placed on the mother’s perineum (in case of vaginal delivery) or on the thigh (in case of caesarean section), the clamping and cutting of umbilical cord will be delayed for at least 30 seconds but not more than 60 seconds. During the first 30 second, the obstetrician can perform initial resuscitation steps, including providing warmth, newborn repositioning, airway clearance, drying, suctioning, and stimulating. In infants who response well to initial resuscitation, the clamping and cutting of the cord will be delayed until 60 seconds. However, in infants who do not responded to initial resuscitation or appear non‐vigorous, the cord will be clamped and cut at 30 seconds or at any time during 30 to 60 seconds. Comparator: ECC Clamping at < 10 secs In the ECC group, after each infant is delivered, the umbilical cord will be clamped and cut immediately by obstetrician (less than 10 seconds).
Outcomes	Primary Infants' Hct level at birth Secondary Echo‐cardiogram measurement Other maternal and infants' relevance clinical outcomes
Starting date	1 March 2016
Contact information	Chayatat Ruangkit, Division of Neonatology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Bangkok 10400, Thailand. Email: chayatatr@hotmail.com
Notes	Trial reg: TCTR20170125001 Funding source: Faculty of Medicine Ramathibodi Hospital Research Fund Declaration of interest: no information Comparisons 1 and 2