Varanattu 2017.

Trial name or title	Effect of intact umbilical cord milking versus immediate cord clamping on neonatal outcomes and first year neurodevelopmental outcomes in very preterm infants ‐ a randomised controlled trial
Methods	Randomised parallel assignment
Participants	Inclusion criteria Infants < 32 weeks' gestation Exclusion criteria
Interventions	Intervention: UCM Immediately after delivery, the infant will be placed at or ∼20 cm below the level of the placenta and about 20 cm of the intact umbilical cord will be milked towards the umbilicus 3 times. The technique consists of pinching the cord close to the placenta and milking about 20 cm segment of the cord proximal to the umbilicus, towards the infant over a 2‐second duration. The cord will then be released and allowed to refill with blood for a brief 2‐second pause between each milking motion. After completion of milking 3 times, the cord will be clamped close to the umbilicus and the neonate handed over to the neonatal team. The procedure of cord milking will be completed within 20 seconds. Comparator: ECC Umbilical cord will be clamped immediately after delivery and baby will be handed over to the neonatal team.
Outcomes	Primary Hb at birth Incidence and severity of IVH in the first week of life ‐ cranial ultrasound done on day 7 Resuscitation interventions Secondary Hypotension Inotropic support Sepsis
Starting date	Anticipated 1 September 2017
Contact information	Manoj Varanattu, Email: manojvaranattu@gmail.com Varghese PR, Email: drprvarghese@gmail.com
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