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. 2019 Sep 17;2019(9):CD003248. doi: 10.1002/14651858.CD003248.pub4

Xie 2017.

Trial name or title Study on umbilical cord milking to prevent and decrease the severity of anaemia in preterms
Methods Randomised, parallel assignments
Participants Inclusion criteria
  • Women in labour or with a plan for delivery at a gestational age less than 34 weeks' gestation

  • Singleton pregnancy

  • Informed consent was obtained from the parent


Exclusion criteria
  • Multiple gestation; diagnosis of any of the following in the current pregnancy: haemorrhage requiring clinic/hospital admission; placental abnormalities; fetal anomalies; Down's syndrome of the fetus; anaemia; diagnosis of pre‐eclampsia or eclampsia in current or previous pregnancies; diagnosis at any time for the mother of any of the following: serious diabetes, serious hypertension, chronic renal disease; infant with major congenital malformation; infant with blood disease; unwilling to return for follow‐up study visits at the hospital

Interventions Intervention: UCM
  • Infants were placed at or below level of the placenta and about 25 cm of the umbilical cord was vigorously milked towards the umbilicus 2 to 3 times before clamping the cord. The milking speed was about 25 cm/2 seconds


Comparator: ECC
  • Umbilical cord was clamped immediately, or as close as possible, after delivery of the infant's shoulders. (This was standard practice in the study hospital, thus it served as the "control" group.)

Outcomes Primary
  • Hb, Hct and ferritin at 48 hours


Secondary
  • Hyperbilirubinemia requiring phototherapy

  • Infant blood transfusions

  • Length of admission

  • Complications

Starting date 30 June 2017
Contact information Lijuan Xie, director, Email: xlj68115@sina.com
Notes Setting: China
Sponsors: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine