Table 4. Regulation of pAKT and p4E-BP1 in monocytes. Inhibition (percent change from baseline) for pAKT and p4E-BP1 in monocytes of patients initially dosed with 45 mg or 30 mg CC-223.

	pAKT						p4E-PB1
	30 mg/day			45 mg/day			30 mg/day			45 mg/day
	C1D1 1.5 h	C1D15 0 h	C1D15 1.5 h	C1D1 1.5 h	C1D15 0 h	C1D15 1.5 h	C1D1 1.5 h	C1D15 0 h	C1D15 1.5 h	C1D1 1.5 h	C1D15 0 h	C1D15 1.5 h
n	21	15	15	13	9	8	21	15	15	13	9	8
Median	–59	–63	–79	–83	–43	–76	–9	–18	–26	–37	–27	–47
Mean	–56	–45	–65	–79	–40	–78	–9	–13	–30	–31	–29	–41
SD	25	42	31	13	43	9	20	29	30	35	35	29
Min	–94	–94	–93	–99	–93	–89	–55	–65	–79	–85	–79	–68
Max	–7	42	23	–44	44	–67	26	35	26	46	27	23

C, cycle; D, day; h, hour; pAKT, protein kinase B; p4E-BP1, 4E-binding protein 1; SD, standard deviation.