Table 6.
Association of Study Variables with Lipid Derangements in Patients.
| Explanatory Variables | TC ≥ 200 mg/dL | HDL-C < 40 mg/dL | LDL-C ≥130 mg/dL | TG ≥ 150 mg/dL |
|---|---|---|---|---|
| AOR (99% CI) | AOR (99% CI) | AOR (99% CI) | AOR (99% CI) | |
| Use of PIs | ||||
| ATV/r | 1.00 | 1.00 | 1.00 | 1.00 |
| LPV/r | 2.5 (1.26-5.10) | 0.6 (0.30-1.12) | NA | 2.7 (1.34-5.53) |
| P value | .001 | .03 | NA | .0003 |
| Age-group, years | ||||
| Age < 40 | 1.00 | 1.00 | 1.00 | 1.00 |
| Age ≥ 40 | 3.3 (1.43-7.44) | 0.6 (0.28-1.42) | NA | 2.5 (1.0-6.4) |
| P value | .0002 | .15 | NA | .01 |
| Sex | ||||
| Male | 1.00 | 1.00 | 1.00 | 1.00 |
| Female | 2.5 (1.15-5.28) | 0.5 (0.25-1.16) | 5.0 (0.48-52.03) | 0.4 (0.19-0.85) |
| P value | .002 | .04 | .08 | .002 |
| Alcohol intake | ||||
| Nondrinker | 1.00 | 1.00 | 1.00 | 1.00 |
| Drinker | 1.1 (0.46-2.70) | 1.7 (0.68-4.24) | 1.1 (0.02-50.23) | 0.6 (0.23-1.59) |
| P value | .76 | .14 | .97 | .18 |
| Smoking | ||||
| Nonsmoker | 1.00 | 1.00 | 1.00 | 1.00 |
| Smoker | 0.8 (0.07-8.09) | 0.9 (0.09-10.07) | NA | 1.4 (0.16-11.98) |
| P value | .77 | .94 | NA | .7 |
| BMI, kg/m2 | ||||
| BMI < 25 | 1.00 | 1.00 | 1.00 | 1.00 |
| BMI ≥ 25 | 2.5 (1.21-5.00) | 0.5 (0.28-1.06) | 8.1 (1.25-52.53) | 0.75 (0.37-1.55) |
| P value | .001 | .02 | .004 | .31 |
| Duration of PI use | ||||
| <55 months of use | 1.00 | 1.00 | 1.00 | 1.00 |
| ≥ 55 months of use | 0.8 (0.31-2.19) | 1.5 (0.58-4.02) | NA | 0.36 (0.12-1.08) |
| P value | .610 | .26 | NA | .02 |
| Duration of HIV | ||||
| <42 months | 1.00 | 1.00 | 1.00 | 1.00 |
| ≥ 42 months | 1.2 (0.19-7.09) | 1.1 (0.22-5.80) | 0.4 (0.02-7.45) | 7.7 (0.93-64.17) |
| P value | .830 | .85 | .42 | .01 |
| Comorbidities | ||||
| Without diseases | 1.00 | 1.00 | 1.00 | 1.00 |
| With diseases | 0.4 (0.07-2.14) | 0.2 (0.03-1.40) | 51.4 (0.95-2780.17) | 1.0 (0.17-4.71) |
| P value | .150 | .03 | .01 | .86 |
| Co Medication | ||||
| Not on medication | 1.00 | 1.00 | 1.00 | 1.00 |
| On medication | 6.6 (0.82-53.64) | 2.4 (0.50-11.32) | NA | 7.2 (1.47-35.68) |
| P value | .02 | .16 | NA | .001 |
| Exercise | ||||
| No regular exercises | 1.00 | 1.00 | 1.00 | 1.00 |
| Performing regular exercises | 1.0 (0.43-2.28) | 0.9 (0.38-1.93) | 1.2 (0.09-17.62) | 1.6 (0.70-3.80) |
| P value | .98 | .63 | .84 | .14 |
Abbreviations: AOR, Adjusted Odds Ratio; ATV/r, atazanavir boosted with ritonavir; BMI, body mass index; CI, confidence interval; HDL-C, high-density lipoprotein cholesterol; LDL-C, Low-density lipoprotein cholesterol; LPV/r, lopinavir boosted with ritonavir; NA, not available; PI, protease inhibitor; TC, total cholesterol; TG, triglyceride.