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. 2019 Jun 14;11(6):1064–1076. doi: 10.1080/19420862.2019.1624127

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — Analytical method profiles for ADC and its corresponding mAb intermediate: (A) Hydrophobic Interaction Chromatograph (HIC); (B) Zoom in HIC profile (Peak # 1–6 are indicated); (C) Reverse Phase Liquid Chromatograph (RP-LC); (D) non-reduced CE-SDS; (E) Size Exclusion Chromatograph (SEC); and (F) Analytical Ultracentrifuge (AUC).