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Hinge region O-glycosylation of IgG1 Fc-fusion proteins. A part of the hinge region and CH2-domain sequences of IgG1 and the Fc-fusion proteins etanercept, atacicept and CTLA4-Ig are shown. Disulfide bonds and reported O-glycosylation sites for etanercept,28,29 CTLA4-Ig30 and atacicept are highlighted. Amino acid numbering by Edelman et al.31 OG, O-glycan.
