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. 2019 Jul 24;11(7):1219–1232. doi: 10.1080/19420862.2019.1635865

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — Intact and reduced mass analysis of human IgG1s mAb1 and mAb2, and bispecific IgG-fusion protein BsAbA expressed in Chinese hamster ovary cells. Deconvoluted mass spectra of (a) the N-deglycosylated mAb1, and (b) the reduced light chain (Lc) of mAb1 (solid line) and mAb1-related antibody mAb2 (dotted line). (c) Schematic illustration of BsAbA consisting of four different chains and based on the CrossMab^CH1-CL format including three 4–1BB ligand domains (light grey) allocated to chain A and B. * denotes glycine-serine linkers. (d) Mass spectrum of the N-deglycosylated and reduced BsAbA (chain A, charge state z: 25; chain B, charge state z: 42).