Table 4. Effects of theaflavin on glycogen metabolism in control and experimental animals.
Groups | Glycogen synthase (µ moles of UDP formed/h/mg protein) | Glycogen phosphorylase (µ moles Pi liberated/h/mg protein) | Liver glycogen (mg/g tissue) | Muscle glycogen (mg/g tissue) |
---|---|---|---|---|
Control | 820.16 ± 7.13 | 587.33 ± 7.20 | 46.83 ± 2.48 | 17.50 ± 1.64 |
Normal + Theaflavin 100 mg/kg b.wt | 817.66 ± 6.77 | 586.50 ± 5.20 | 47.66 ± 2.58 | 17.83 ± 1.47 |
Diabetes | 514.83 ± 13.22 | 787.50 ± 11.58b | 21.83 ± 4.40c | 10.66 ± 0.81 |
Diabetic + Theaflavin 100 mg/kg b.wt | 795.66 ± 10.63 | 660.83 ± 9.17b | 35.50 ± 4.37c | 15.50 ± 1.51 |
Diabetic + Metformin 100 mg/kg b.wt | 798.40 ± 11.20 | 662.55 ± 8.46 | 37.67 ± 4.80 | 17.80 ± 1.42 |
Notes: Values are given as mean ± SD for six animals in each group. Values are considered significantly different at P < 0.05 with post hoc LSD test *P < 0.05.
aControl vs. Drug control (Theaflavin alone treated rats).
bControl rats vs. Diabetic rats.
cDiabetic rats vs. Theaflavin 100 mg/kg.
dDiabetic rats treated with Theaflavin 100 mg/kg vs. Metformin (500 mg/kg).