Table 7. Effect of theaflavin on the activities SOD, CAT, GPX and GST in control and experimental rats.
| Groups | Superoxide dismutase | Catalase | Glutathione peroxidase | Glutathione-S-transferase | ||||
|---|---|---|---|---|---|---|---|---|
| Liver | Kidney | Liver | Kidney | Liver | Kidney | Liver | Kidney | |
| Control | 7.19 ± 0.46 | 8.80 ± 0.50 | 75.24 ± 4.01 | 36.95 ± 3.12 | 8.68 ± 0.63 | 7.42 ± 0.58 | 8.53 ± 0.52 | 5.76 ± 0.46 |
| Normal + Theaflavin (100 mg/kg b.wt) | 7.52 ± 0.43 | 9.21 ± 0.51 | 77.00 ± 3.88 | 37.31 ± 3.17 | 9.22 ± 0.71 | 7.77 ± 0.57 | 8.92 ± 0.41 | 6.15 ± 0.38 |
| Diabetes Induced | 3.15 ± 0.27b | 3.74 ± 0.35b | 49.57 ± 3.75 | 24.73 ± 2.35b | 5.19 ± 0.42 | 4.91 ± 0.44b | 4.06 ± 0.31b | 3.41 ± 0.33b |
| Diabetic + Theaflavin (100 mg/kg b.wt) | 7.28 ± 0.36c | 7.01 ± 0.40c | 68.11 ± 4.06c | 32.93 ± 2.81c | 7.70 ± 0.71c | 7.00 ± 0.53c | 7.67 ± 0.52c | 4.83 ± 4.63c |
| Diabetic + Metformin (500 mg/kg b.wt) | 7.57 ± 0.37 | 7.30 ± 0.39 | 70.16 ± 4.26 | 36.33 ± 3.25 | 7.31 ± 0.77 | 7.61 ± 0.67 | 7.20 ± 0.46 | 5.21 ± 0.37 |
Notes: Values are given as mean ± SD for six animals in each group. Values are considered significantly different at P < 0.05 with post hoc LSD test *P < 0.05. The activities of enzymes are expressed as follows: SOD – One unit of activity was taken as the enzyme quantity, which gave 50% inhibition of nitroblue tetrazolium reduction in 1 min/mg protein; CAT – µmoles of H2O2 consumed/minute; GPx – µg of glutathione consumed/minute/mg protein; GST- µmoles of 1-chloro 2,4-dinitrobenzene-GSH conjugate formed/minute/mg protein.
aControl vs. Drug control (Theaflavin alone treated control rats).
bControl rats vs. Diabetic rats.
cDiabetic rats vs. Theaflavin treated diabetic rats.
dTheaflavin treated diabetic rats vs. Metformin treated diabetic rats.