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Incorporation of CH1/CL charge pair variants increases BsIgG1 yields for antibody pairs that have a strong intrinsic HC/LC pairing preference. For the charge pair variants, the first listed antibody contains the CL V133E and CH1 S183K mutations and the second listed antibody contains the CL V133K and CH1 S183E mutations.21 See Table 1 for additional experimental details. 90% yield of BsIgG1 is indicated by a dotted horizontal line.
