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. 2019 Jul 26;11(7):1254–1265. doi: 10.1080/19420862.2019.1640549

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 4. — Contributions of CDR L3 and H3 to bispecific yield for (a) anti-EGFR/MET and (b) anti-IL-13/IL-4 BsIgG₁. CDR L3 and H3 for one of both arms of each BsIgG₁ were replaced with corresponding sequences from an anti-CD3 antibody to investigate their contribution to BsIgG₁ yield. Data plotted are the mean ± SD of two independent experiments from optimized LC DNA ratios. See Table 1 for additional experimental details.