Figure 5.

Combined effects of LBL-007 and anti-PD-1 antibody on inhibition of mouse colorectal cancer cell growth in vivo.

C57BL/6-hLAG-3 mice (n = 40) were randomized (n = 8 mice/group) when MC38 colon adenocarcinoma tumor volumes reached approximately 80 mm³. (A) Tumor volumes after treatment with the vehicle (PBS), isotype control, anti-PD-1, LBL-007 or a combination of LBL-007 and anti-PD-1 antibody (10 mg/kg each, twice a week). (B) Tumor tissues were weighed. Data are presented as mean tumor volume ± SEM. **P < .01, and ***P < .001 by one-way ANOVA.