Table 1.
Significant relative levels of mRNA, protein and phosphorylated protein following three days of treatment with Raloxifene and/or PX-866.
| Micromolar treatment | TERT | p21 | Cyc D1 | Axin2 | LIF | HB EGF | DEC1 |
|---|---|---|---|---|---|---|---|
| Control | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| 1.0 Raloxifene | 0.328* | 0.158* | 0.338* | ||||
| 0.4 PX-866 | |||||||
| Raloxifene+0.1 PX-866 | 0.396* | 0.398* | 0.260* | 0.283* | 0.370* | ||
| Raloxifene+0.4 PX-866 | 0.539* | 0.336* | |||||
| Raloxifene+0.8 PX-866 | 2.76* | 0.356* | 1.95* | ||||
| Micromolar treatment | pMDM2 protein | ||||||
| Control | 1.0 | ||||||
| 1.0 Raloxifene | |||||||
| 0.4 PX-866 | 0.379* | ||||||
| Raloxifene +0.1 PX-866 | 0.395* | ||||||
| Raloxifene +0.4 PX-866 | 0.385* | ||||||
| Raloxifene +0.8 PX-866 | 0.353* | ||||||
p<0.05.