CRAMP KO increased the amount of taurine, NA, and SCFAs in AF mice. (A) Overlap of significantly changed metabolites between AF-WT mice and AF-KO mice detected by GC × GC-MS, 2DLC-MS (−), and 2DLC-MS (+). (B) Changes of taurine and NA detected by all three platforms in feces of AF-WT mice and AF-KO mice. (C) Quantification results of SCFAs in feces of AF-WT mice and AF-KO mice. ** p < 0.01. AF, alcohol-fed; WT, wild type; KO, CRAMP knockout.