. 2019 Aug 23;62(17):7788–7805. doi: 10.1021/acs.jmedchem.9b00582

Table 1. Structures and IC₅₀ Values for Thienopyrimidinone PaTrmD Inhibitors^a.

Biochemical potency is represented as IC₅₀ value (μM); values are mean ± SD for at least two independent experiments done in duplicate.

The listed pharmacophores replace the group N(R1)(R2).

Table 1. Structures and IC50 Values for Thienopyrimidinone PaTrmD Inhibitorsa.