Table 5. Antibacterial Activities (μM) for Selected Thienopyrimidinone Analogues.

		15			23			24
	pathogen	MIC50a	MIC90a	MBC99.9b	MIC50	MIC90	MBC99.9	MIC50	MIC90	MBC99.9
Gram-negative	P. aeruginosa	NAc	NA	NA	NA	NA	NA	NA	NA	NA
	A. baumannii	62	95	>100	>100	>100	>100	75	99	>100
	K. pneumoniae	NA	NA	NA	NA	NA	NA	NA	NA	NA
	S. enteritidis	NA	NA	NA	NA	NA	NA	>100	>100	>100
	E. coli	NA	NA	NA	NA	NA	NA	NA	NA	NA
Gram-positive	S. aureus	31	36	54	6	8.5	34	5	8.5	34
	E. faecalis	NA	NA	NA	NA	NA	NA	NA	NA	NA
	S. pneumoniae	60	73	>100	34	56	>100	62	74	>100
mycobacteria	M. smegmatis	58	72	>100	13	18	36	17	23	69
	M. tuberculosis	78	>100d	>100	22	43	75	44	88	nde

^aMIC₅₀ and MIC₉₀ represent hit concentrations inhibiting growth by 50% and 90%, respectively.

^bMBC_99.9 represents hit concentrations kill bacteria by 99.9%.

^cNA = no bacterial activity.

^dDenotes detectable growth inhibition or bactericidal activity but less than 50% for MIC₅₀, less than 90% for MIC₉₀, and less than 99.9% for MBC_99.9.

^end = not determined.