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. 2019 Jul 26;16(9):3968–3976. doi: 10.1021/acs.molpharmaceut.9b00585

Figure 1.

Figure 1

Simulation model for timolol distribution to the lens after topical dosing, extended from ref (25). VTF, tear fluid volume; CLTF,CJ, clearance from tear fluid by conjunctival absorption; CLTT, clearance from tear fluid by tear turnover; CLdrain, clearance from tear fluid by drainage of the instilled solution; CLTF,CO, clearance from tear fluid by corneal absorption; kD, corneal desorption rate constant; VAQ, aqueous humor volume; kel, elimination rate constant; QRESERVOIR, distribution clearance between aqueous humor and reservoir; VRESERVOIR, reservoir volume; Kp, lens/buffer partition coefficient; QLENS, distribution clearance between aqueous humor and the lens; VLENS, lens volume.