Table 1. Simulated Timolol Concentrations and AUCs in the Aqueous Humor and Lens with Various Lens/Buffer Partition Coefficients (K_p) and Dosing Schemes.

			Kp
			0.35	1.05	3.5
single dose of 125 μg (25 μL)	aqueous humor	Cmax (μg/mL)	2.79	2.79	2.79
		AUC0–14days (μg·min/mL)	318	318	318
	lens	Cmax (μg/mL)	0.28	0.36	0.42
		AUC0–14days (μg·min/mL)	111	333	1111
125 μg (25 μL) once daily	aqueous humor	Cmax,ss (μg/mL)	2.79	2.79	2.80
		Cmin,ss (μg/mL)	0.00	0.00	0.00
	lens	Cmax,ss (μg/mL)	0.28	0.43	0.95
		Cmin,ss (μg/mL)	0.00	0.08	0.58
125 μg (25 μL) three times daily	aqueous humor	Cmax,ss (μg/mL)	2.80	2.81	2.81
		Cmin,ss (μg/mL)	0.01	0.02	0.02
	lens	Cmax,ss (μg/mL)	0.34	0.80	2.42
		Cmin,ss (μg/mL)	0.11	0.55	2.16