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Net risk of ipsilateral invasive breast cancer (iIBC) based on retrospective cohort studies of ductal carcinoma in situ patients without locoregional treatment. The cumulative net risk of iIBC in the pooled retrospective cohort studies is shown for all cases combined (A) and stratified by tumor grade (B) and age at diagnosis (C). The number of patients at risk is shown beneath the figures. Subgroup comparisons were performed using a log-rank test.
