Table 3.
SMR and AER for selected cancers by years since treatment for hereditary retinoblastoma
| Cancer type | Age, y |
||||
|---|---|---|---|---|---|
| <15 | 15–29 | 30–44 | 45–59 | ≥60 | |
| All subsequent cancers | |||||
| O | 55 | 69 | 74 | 55 | 14 |
| SMR* (95% CI) | 71.1 (53.5 to 92.5) | 89.9 (70.0 to 113.8) | 33.6 (26.4 to 42.2) | 14.1 (10.7 to 18.4) | 6.7 (3.6 to 11.2) |
| AER | 38.0 | 62.1 | 97.6 | 196.4 | 327.5 |
| Bone | |||||
| O | 31 | 33 | 9 | 5 | 1 |
| SMR* (95% CI) | 886.5 (602.2 to >1000) | 695.9 (479.0 to 977.4) | 591.4 (269.9 to >1000) | 539.3 (173.8 to >1000) | — |
| AER | 21.7 | 30.0 | 12.2 | 19.2 | — |
| Soft tissue sarcoma and connective tissue | |||||
| O | 4 | 12 | 18 | 14 | 4 |
| SMR* (95% CI) | 166.1 (44.7 to 425.2) | 316.4 (163.3 to 552.8) | 410.1 (242.9 to 648.1) | 380.5 (207.8 to 638.5) | 318.6 (85.7 to 815.6) |
| AER | 2.8 | 10.9 | 24.4 | 53.6 | 109.8 |
| Nasal cavities, middle ear and sinus | |||||
| O | 4 | 5 | 2 | 4 | 0 |
| SMR* (95% CI) | >1000 (>1000 to >1000) | >1000 (969.8 to >1000) | 521.6 (58.6 to >1000) | 916.6 (246.6 to >1000) | — |
| AER | 2.8 | 4.5 | 2.7 | 15.4 | — |
| Melanoma | |||||
| O | 1 | 8 | 4 | 2 | 0 |
| SMR* (95% CI) | — | 210.4 (90.6 to 414.5) | 37.9 (10.2 to 97.1) | 21.3 (2.4 to 77.0) | — |
| AER | — | 7.2 | 5.3 | 7.3 | — |
| Brain, and other parts of the nervous system | |||||
| O | 8 | 0 | 7 | 2 | 0 |
| SMR* (95% CI) | 44.6 (19.2 to 87.9) | — | 42.9 (17.2 to 88.4) | 12.6 (1.4 to 45.4) | — |
| AER | 5.5 | — | 9.3 | 7.1 | — |
| Lung and trachea | |||||
| O | 1 | 1 | 5 | 5 | 0 |
| SMR* (95% CI) | — | — | 15.5 (5.0 to 36.1) | 4.8 (1.5 to 11.2) | — |
| AER | — | — | 6.4 | 15.2 | — |
| Corpus uteri | |||||
| O | 0 | 0 | 4 | 4 | 1 |
| SMR* (95% CI) | — | — | 202.5 (54.5 to 518.4) | 81.2 (21.8 to 207.9) | — |
| AER | — | — | 11.7 | 31.1 | — |
| Bladder | |||||
| O | 0 | 0 | 2 | 4 | 1 |
| SMR* (95% CI) | — | — | 130.0 (14.6 to 469.4) | 79.0 (21.3 to 202.3) | — |
| AER | — | — | 2.7 | 15.2 | — |
*
SMRs, CIs, and AERs not presented for deaths <2. AER = absolute excess risk per 10 000 person-years; CI = confidence interval; O = observed number of cancer deaths; SMR = standardized mortality ratio.