Table 1.
Baseline Characteristics by Randomized Group
| Treatment | |||||
|---|---|---|---|---|---|
| Overall (N = 289) | Placebo (N = 102) | Losartan Only (N = 39) | Fish oil (N = 122) | Combination (N = 26) | |
| Age in years | 77.6 ± 5.4 | 77.4 ± 5.3 | 77.3 ± 4.9 | 78.0 ± 5.6 | 77.2 ± 5.6 |
| Age | |||||
| 70–79 y | 186 (87.3%) | 67 (90.5%) | 25 (89.3%) | 76 (81.7%) | 18 (100%) |
| 80–89 y | 20 (9.4%) | 6 (8.1%) | 3 (10.7%) | 11 (11.8%) | 0 (0.0%) |
| 90+ y | 7 (3.3%) | 1 (1.4%) | 0 (0.0%) | 6 (6.5%) | 0 (0.0%) |
| Female % | 137 (47.4%) | 49 (48.0%) | 18 (46.2%) | 58 (47.5%) | 12 (46.2%) |
| White % | 225 (77.9%) | 81 (79.4%) | 27 (69.2%) | 95 (77.9%) | 22 (84.6%) |
| African American % | 49 (17.0%) | 17 (16.7%) | 8 (20.5%) | 21 (17.2%) | 3 (11.5%) |
| Other/Mixed Race % | 15 (5.2%) | 4 (3.9%) | 4 (10.3%) | 6 (4.9%) | 1 (3.8%) |
| Hispanic % | 7 (2.4%) | 2 (2.0%) | 2 (5.1%) | 3 (2.5%) | 0 (0.0%) |
| Education | |||||
| Elementary School (K-08) | 3 (1.0%) | 1 (1.0%) | 1 (2.6%) | 1 (0.8%) | 0 (0.0%) |
| High School/Equivalent (09−12) | 87 (30.1%) | 26 (25.5%) | 9 (23.1%) | 46 (37.7%) | 6 (23.1%) |
| College (13−16) | 120 (41.5%) | 48 (47.1%) | 18 (46.2%) | 42 (34.4%) | 12 (46.2%) |
| Post Graduate | 69 (23.9%) | 24 (23.5%) | 9 (23.1%) | 28 (23.0%) | 8 (30.8%) |
| Other | 10 (3.5%) | 3 (2.9%) | 2 (5.1%) | 5 (4.1%) | 0 (0.0%) |
| BMI | 31.4 ± 5.7 | 31.1 ± 5.2 | 32.1 ± 6.9 | 31.5 ± 5.6 | 31.3 ± 6.0 |
| Weight in kg | 87.0 ± 17.8 | 86.5 ± 16.7 | 90.3 ± 19.5 | 86.4 ± 17.2 | 86.8 ± 21.8 |
| MMSE | 28.0 ± 1.7 | 27.9 ± 1.7 | 28.2 ± 1.6 | 28.1 ± 1.6 | 28.0 ± 1.9 |
| 400 m Walk Speed | 0.8 ± 0.2 | 0.8 ± 0.2 | 0.9 ± 0.2 | 0.8 ± 0.2 | 0.8 ± 0.2 |
| SPPB Total Score | 8.7 ± 2.1 | 8.4 ± 2.2 | 8.6 ± 2.1 | 8.9 ± 1.9 | 8.7 ± 2.0 |
| IL6: median and IQ range | 3.7 (2.8, 4.9) | 4.0 (2.8, 5.0) | 3.8 (3.1, 4.5) | 3.7 (2.8, 5.1) | 3.2 (2.4, 4.1) |
| Systolic Blood Pressure mmHg | 135.5 ± 18.0 | 133.2 ± 17.7 | 139.8 ± 13.8 | 135.1 ± 19.8 | 139.7 ± 14.0 |
| Diastolic Blood Pressure mmHg | 72.2 ± 10.1 | 71.4 ± 10.8 | 77.5 ± 8.5 | 70.3 ± 9.3 | 75.8 ± 9.2 |
| Grip Strength Right Hand kg | 25.4 ± 8.8 | 25.4 ± 8.1 | 26.6 ± 10.1 | 25.2 ± 8.6 | 24.1 ± 10.0 |
| Grip Strength Left Hand kg | 24.6 ± 8.6 | 24.5 ± 8.3 | 26.0 ± 9.6 | 24.2 ± 8.3 | 25.0 ± 10.0 |
| Hypertension | 200 (69.2%) | 71 (69.6%) | 22 (56.4%) | 96 (78.7%) | 11 (42.3%) |
| Cancer | 109 (37.7%) | 38 (37.3%) | 9 (23.1%) | 51 (41.8%) | 11 (42.3%) |
| Diabetes | 68 (23.5%) | 27 (26.5%) | 3 (7.7%) | 37 (30.3%) | 1 (3.8%) |
| Myocardial Infarction | 26 (9.0%) | 10 (9.8%) | 2 (5.1%) | 13 (10.7%) | 1 (3.8%) |
| Congestive Heart Failure | 8 (2.8%) | 2 (2.0%) | 0 (0.0%) | 6 (4.9%) | 0 (0.0%) |
| Stroke | 13 (4.5%) | 6 (5.9%) | 2 (5.1%) | 4 (3.3%) | 1 (3.8%) |
| Palpitations | 44 (15.2%) | 20 (19.6%) | 8 (20.5%) | 14 (11.5%) | 2 (7.7%) |
Note: BMI = Body mass index; MMSE = Mini-Mental State Examination; SPPB = short physical performance battery.