Table 3. Summary of other bevacizumab studies.
Article | Sample size | Dose | Median treatment time | Response |
---|---|---|---|---|
Plotkin et al 8 | 10 patients | 5 mg/kg every 2 weeks | 12 months | 90% with reduction in tumor size |
Plotkin et al 9 | 31 patients | 5 mg/kg every 2 weeks | 14 months | Freedom from progression in 88% by 1 year and 67% by 2 years |
Alanin et al 10 | 12 patients | First 6 months: 10 mg/kg every 2 weeks Maintenance: 15 mg/kg every 3 weeks |
22 months | Reduction in tumor volume in 88% |
Current study | 7 patients | First 6 months: 10 mg/kg every 2 weeks Maintenance: 5 mg/kg every 3 weeks |
33 months | Freedom from linear and volumetric progression, respectively: 1 year: 90%, 100% 2 years: 79%, 88% 3 years: 53%, 70% |