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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Schizophr Res. 2019 Mar 18;217:17–25. doi: 10.1016/j.schres.2019.03.007

Figure 4. Cellulo-spatio-temporal resolution of Hi-C defined schizophrenia risk genes.

Figure 4.

Schizophrenia risk genes were defined by having more than two sources of Hi-C evidence from adult brains, fetal brains, neural progenitor cells (NPC), and neurons. A. Developmental expression trajectory of Hi-C defined schizophrenia risk genes suggests midgestation and postnatal periods as critical windows. B. Regional enrichment of schizophrenia risk genes in the frontal cortex. C. Single-cell expression values of schizophrenia risk genes highlight excitatory neurons as central cell types. Ctx, cortex; Ex, excitatory neurons; In, inhibitory neurons; OPC, oligodendrocyte precursor cells.